T lymphocyte lines isolated from atheromatous plaque contain cells capable of responding to Chlamydia antigens.

@article{Curry2000TLL,
  title={T lymphocyte lines isolated from atheromatous plaque contain cells capable of responding to Chlamydia antigens.},
  author={Allison J. Curry and I Portig and J C Goodall and Peter John Kirkpatrick and J. S. Hill Gaston},
  journal={Clinical and experimental immunology},
  year={2000},
  volume={121 2},
  pages={261-9}
}
Chlamydia pneumoniae infection is associated with atherosclerosis and the organism has been identified in arterial lesions. To determine whether T lymphocyte-mediated immune responses to Chlamydia antigens within plaque could contribute to pathogenesis, we have derived T cell lines from atherosclerotic plaques of 32 patients. Culture with IL-2 alone proved insufficient for cellular activation and expansion, but additional stimulation with phytohaemagglutinin (PHA) or recall antigens allowed… CONTINUE READING

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