T-lymphocyte killing by T101-ricin A-chain immunotoxin: pH-dependent potentiation with lysosomotropic amines.

@article{Casellas1988TlymphocyteKB,
  title={T-lymphocyte killing by T101-ricin A-chain immunotoxin: pH-dependent potentiation with lysosomotropic amines.},
  author={Pierre Casellas and Sophie Ravel and Bernard Bourri{\'e} and Jean Marie Derocq and Franz Klaus Jansen and G{\'e}rard Laurent and Philippe Gros},
  journal={Blood},
  year={1988},
  volume={72 4},
  pages={
          1197-202
        }
}
To maximize T-lymphocyte killing with anti-pan-T-lymphocyte immunotoxin (IT), prepared by linking ricin A-chain to monoclonal antibody (MoAb) T101 (T101-RTA IT), we have established the nature and the extent of parameters that influence the sensitivity of T lymphocytes to the IT. We showed that peripheral blood T lymphocytes, which are much less susceptible than malignant T cells to the T101-RTA IT, could become highly sensitive to the IT when used in conjunction with NH4Cl. However… CONTINUE READING

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