T-lymphocyte interleukin 2-dependent tyrosine protein kinase signal transduction involves the activation of p56lck.

@article{Horak1991TlymphocyteI2,
  title={T-lymphocyte interleukin 2-dependent tyrosine protein kinase signal transduction involves the activation of p56lck.},
  author={Ivan D. Horak and Ronald E Gress and Philip J. Lucas and Eva M. Horak and Thomas A. Waldmann and Joseph B. Bolen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 5},
  pages={1996-2000}
}
Addition of interleukin 2 (IL-2) to IL-2-dependent T cells results in tyrosine protein kinase signal transduction events even though the IL-2 receptor alpha and beta chains lack intrinsic enzymatic activity. Here we report that addition of IL-2 to IL-2-dependent human T cells transiently stimulates the specific activity of p56lck, a member of the src family of nonreceptor tyrosine protein kinases expressed at high levels in T lymphocytes. The ability of IL-2 to induce p56lck activation was… CONTINUE READING

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