T lymphocyte-endothelial cell interactions.

  title={T lymphocyte-endothelial cell interactions.},
  author={Jaehyuk Choi and David R. Enis and Kian Peng Koh and Stephen L. Shiao and Jordan S Pober},
  journal={Annual review of immunology},
Human vascular endothelial cells (EC) basally display class I and II MHC-peptide complexes on their surface and come in regular contact with circulating T cells. We propose that EC present microbial antigens to memory T cells as a mechanism of immune surveillance. Activated T cells, in turn, provide both soluble and contact-dependent signals to modulate normal EC functions, including formation and remodeling of blood vessels, regulation of blood flow, regulation of blood fluidity, maintenance… CONTINUE READING