T lymphocyte autoimmunity in peripheral nervous system autoimmune disease

  title={T lymphocyte autoimmunity in peripheral nervous system autoimmune disease},
  author={Christopher Linington and Hartmut Wekerle and Richard Meyermann},
  journal={Agents and Actions},
Autoaggressive T cells specific for the PNS myelin P2 protein play a central role in the initiation of EAN in the Lewis rat, although there is as yet no direct experimental evidence that the T cells can themselves mediate demyelination in vivo. However, the striking similarities in the pathogenesis of EAN and the Guillain-Barré syndrome suggest that T cell mediated EAN provides an excellent model to study the immunological mechanisms of inflammation and demyelination that are relevant to human… CONTINUE READING
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