T lymphocyte adhesion to the fibronectin and laminin components of the extracellular matrix is regulated by the CD4 molecule.

@article{Hershkoviz1992TLA,
  title={T lymphocyte adhesion to the fibronectin and laminin components of the extracellular matrix is regulated by the CD4 molecule.},
  author={Rami Hershkoviz and Shmuel Miron and Irun R. Cohen and Allison Miller and Ofer Lider},
  journal={European journal of immunology},
  year={1992},
  volume={22 1},
  pages={7-13}
}
The adhesion of T cells to components of the extracellular matrix (ECM) is mediated by the beta 1 subfamily of integrin receptors, designated VLA. It has been recently demonstrated that the binding of VLA receptors to protein components of the ECM is rapidly augmented by the activation of the T cells without, however, any actual change in the level of expression of the VLA receptors for fibronectin (FN) or laminin (LN). Thus, it is likely that activation of existing VLA receptors is required… CONTINUE READING