T-lymphocyte activation in the enlarged thoracic lymph nodes of rats with silicosis.

@article{Garn1997TlymphocyteAI,
  title={T-lymphocyte activation in the enlarged thoracic lymph nodes of rats with silicosis.},
  author={Holger Garn and Anke Friedetzky and Gerald S. Davis and David R Hemenway and Diethard Gemsa},
  journal={American journal of respiratory cell and molecular biology},
  year={1997},
  volume={16 3},
  pages={309-16}
}
Silicosis is primarily a mononuclear cell inflammatory and fibrotic disease of the pulmonary parenchyma. It is known that lung-associated lymph nodes are also affected. To study the involvement of lymphocytes in silicosis, we examined lymph nodes of rats 12 months after an 8-day silica aerosol exposure. We found that 2 thoracic lymph nodes close to the thymus were enormously enlarged in silicotic rats and contained a 49-fold higher cell number than control lymph nodes. The higher cell number… CONTINUE READING
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