T-lymphocyte T4 molecule behaves as the receptor for human retrovirus  LAV

  title={T-lymphocyte T4 molecule behaves as the receptor for human retrovirus  LAV},
  author={David Klatzmann and Eric Champagne and Sophie Chamaret and Jacqueline Gruest and Denise Gu{\'e}tard and Thierry Hercend and J B Gluckman and Luc Montagnier},
Many viruses, including retroviruses, are characterized by their specific cell tropism1–3. Lymphadenopathy-associated virus (LAV) is a human lymphotropic retrovirus isolated from patients with acquired immune deficiency syndrome (AIDS) or related syndromes4,5, that displays selective tropism for a subset of T lymphocytes defined by the expression of a surface glycoprotein of relative molecular mass 62,000 (62K) termed T4 (refs 6–8). This glycoprotein delineates a subset of T lymphocytes with… CONTINUE READING
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