T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation.

@article{Feng2010TlymphoblasticLC,
  title={T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation.},
  author={Hui Feng and David L Stachura and Richard M White and Alejandro Gutierrez and Lu Zhang and Takaomi Sanda and Cicely A. Jette and Joseph R Testa and Donna S Neuberg and David M Langenau and Jeffery L. Kutok and Leonard I. Zon and David Traver and Mark D Fleming and John P. Kanki and A Thomas Look},
  journal={Cancer cell},
  year={2010},
  volume={18 4},
  pages={
          353-66
        }
}
The molecular events underlying the progression of T-lymphoblastic lymphoma (T-LBL) to acute T-lymphoblastic leukemia (T-ALL) remain elusive. In our zebrafish model, concomitant overexpression of bcl-2 with Myc accelerated T-LBL onset while inhibiting progression to T-ALL. The T-LBL cells failed to invade the vasculature and showed evidence of increased homotypic cell-cell adhesion and autophagy. Further analysis using clinical biopsy specimens revealed autophagy and increased levels of BCL2… CONTINUE READING
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