T-helper cells as new players in ANCA-associated vasculitides

  title={T-helper cells as new players in ANCA-associated vasculitides},
  author={Wayel H. Abdulahad and P. N. Lamprecht and Cees G. M. Kallenberg},
  booktitle={Arthritis research & therapy},
In anti-neutrophil cytoplasmic autoantibody-associated vasculitides (AAV), several observations support a key role of T-helper cells (CD4(+) T cells) in disease pathophysiology. An expanded population of effector memory CD4(+) T cells in AAV patients may contribute to tissue injury and disease progression. In addition, functional impairment of regulatory T cells (T(Regs)) is reported in AAV patients. A fraction of T(Regs) have the capacity to differentiate into Th17 cells in the context of a… CONTINUE READING

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