T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells.

@article{Weaver1988THC,
  title={T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells.},
  author={Casey T Weaver and Catherine M Hawrylowicz and Emil R Unanue},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 21},
  pages={8181-5}
}
We examined the ability of macrophages and B cells to function as antigen-presenting cells (APCs) for murine TH1 and TH2 cloned T helper cell lines. Antigen presented by concanavalin A-elicited peritoneal macrophages or resting splenic B cells stimulated antigen-dependent proliferation of both T helper subsets. Paraformaldehyde fixation of the APCs following different conditions of activation indicated differential requirements for costimulatory signals by TH1 and TH2 cells. TH2 proliferative… CONTINUE READING

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