T helper cell polarization in healthy people: implications for cardiovascular disease.

@article{Olson2013THC,
  title={T helper cell polarization in healthy people: implications for cardiovascular disease.},
  author={Nels C. Olson and R. Sallam and Margaret F Doyle and Russell P Tracy and Sally Ann Huber},
  journal={Journal of cardiovascular translational research},
  year={2013},
  volume={6 5},
  pages={772-86}
}
Atherosclerosis is a chronic inflammatory disease characterized by T lymphocyte infiltration into the atherosclerotic plaque. Assessments of T cell subtypes have demonstrated a predominance of CD4(+) T helper (Th) cells, implicated Th1 and Th17 immunity in both human and mouse atherogenesis, and provided some evidence suggesting protective roles of Th2 and T regulatory cells. Observations that certain inbred mouse strains have an inherent T helper bias suggest a genetic predisposition toward… CONTINUE READING
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