T helper-cell phenotype regulates atherosclerosis in mice under conditions of mild hypercholesterolemia.

@article{Huber2001THP,
  title={T helper-cell phenotype regulates atherosclerosis in mice under conditions of mild hypercholesterolemia.},
  author={Sally Ann Huber and Pamela Sakkinen and Chella David and M. Karen Newell and Russell P Tracy},
  journal={Circulation},
  year={2001},
  volume={103 21},
  pages={2610-6}
}
BACKGROUND T cells are implicated in atherosclerosis, but little is known about the genetic control or molecular pathways, especially under conditions of mild hypercholesterolemia. METHODS AND RESULTS BALB/c mice, making a CD4+ Th2 (IL-4+) cell response, express both MHC class II antigens (IA(d), IE(d)) and are atherosclerosis-resistant. C57Bl/6 mice produce a CD4+ Th1 (interferon [IFN]gamma+) response, express IA(b) but no IE, and are atherosclerosis-prone. To evaluate T helper-cell… CONTINUE READING

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