T helper cell- and CD40-dependent germline IgM prevents chronic virus-induced demyelinating disease.

Abstract

Generation of antiviral IgM is usually considered as a marker of a short-lived initial antibody response that is replaced by hypermutated and more-efficient IgG. However, once viruses have established a particular niche for their persistence (e.g., within the CNS), the immune system has to specifically mobilize a broad range of antimicrobial effectors to… (More)
DOI: 10.1073/pnas.1115154109

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