T helper 2-dominant antilymphoma immune response is associated with fatal outcome.

@article{Lee1997TH2,
  title={T helper 2-dominant antilymphoma immune response is associated with fatal outcome.},
  author={Peter P. Lee and Daisy Zeng and A E McCaulay and Yi Fang Chen and Carola Geiler and Dale T. Umetsu and Nelson J Chao},
  journal={Blood},
  year={1997},
  volume={90 4},
  pages={1611-7}
}
The precise role of the endogenous immune system in modulating cancer development remains unclear. Tumor cells are generally thought to be nonimmunogenic because they are of 'self' origin. However, tumor-reactive lymphocytes can be isolated from patients with many types of cancer. It is unclear what role these lymphocytes play and why they fail to protect the host. Using a murine B-cell leukemia/lymphoma (BCL1) model, we showed the development of a vigorous antitumor T-cell response in the… CONTINUE READING