T-helper 17 and interleukin-17-producing lymphoid tissue inducer-like cells make different contributions to colitis in mice.

@article{Ono2012Thelper1A,
  title={T-helper 17 and interleukin-17-producing lymphoid tissue inducer-like cells make different contributions to colitis in mice.},
  author={Yuichi Ono and T. Hosokawa Kanai and Tomohisa Sujino and Yasuhiro Nemoto and Yasumasa Kanai and Yohei Mikami and A. T. Hayashi and Atsuhiro Matsumoto and Hiromasa Takaishi and Haruhiko Ogata and Katsuyoshi Matsuoka and Tadakazu Hisamatsu and Mamoru Watanabe and Toshifumi Hibi},
  journal={Gastroenterology},
  year={2012},
  volume={143 5},
  pages={
          1288-1297
        }
}
BACKGROUND & AIMS T helper (Th) 17 cells that express the retinoid-related orphan receptor (ROR) γt contribute to the development of colitis in mice, yet are found in normal and inflamed intestine. We investigated their development and functions in intestines of mice. METHODS We analyzed intestinal Th17 cells in healthy and inflamed intestinal tissues of mice. We analyzed expression of lymphotoxin (LT)α by Th17 cells and lymphoid tissue inducer-like cells. RESULTS LTα(-/-) and RORγt… CONTINUE READING

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