T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells

@article{Arbore2016TH1,
  title={T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells},
  author={Giuseppina Arbore and Erin E. West and Rosanne Spolski and Avril A B Robertson and Andreas Klos and Claudia Rheinheimer and Pavel Dutow and Trent M Woodruff and Zu Xi Yu and Luke A. J. O’Neill and Rebecca C Coll and Alan Sher and Warren J Leonard and Joerg Koehl and Pete Monk and Matthew A. Cooper and Matthew Arno and Behdad Afzali and Helen Lachmann and Andrew P Cope and Katrin D. Mayer-Barber and Claudia Kemper},
  journal={Science},
  year={2016},
  volume={352}
}
The NLRP3 inflammasome controls interleukin-1β maturation in antigen-presenting cells, but a direct role for NLRP3 in human adaptive immune cells has not been described. We found that the NLRP3 inflammasome assembles in human CD4+ T cells and initiates caspase-1–dependent interleukin-1β secretion, thereby promoting interferon-γ production and T helper 1 (TH1) differentiation in an autocrine fashion. NLRP3 assembly requires intracellular C5 activation and stimulation of C5a receptor 1 (C5aR1… CONTINUE READING
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