T follicular helper cell dynamics in germinal centers.

@article{Shulman2013TFH,
  title={T follicular helper cell dynamics in germinal centers.},
  author={Ziv Shulman and Alexander D. Gitlin and Sasha Targ and Mila Jankovic and Giulia Pasqual and Michel C. Nussenzweig and Gabriel D Victora},
  journal={Science},
  year={2013},
  volume={341 6146},
  pages={
          673-7
        }
}
T follicular helper (T(FH)) cells are a specialized subset of effector T cells that provide help to and thereby select high-affinity B cells in germinal centers (GCs). To examine the dynamic behavior of T(FH) cells in GCs in mice, we used two-photon microscopy in combination with a photoactivatable fluorescent reporter. Unlike GC B cells, which are clonally restricted, T(FH) cells distributed among all GCs in lymph nodes and continually emigrated into the follicle and neighboring GCs. Moreover… CONTINUE READING
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