T cells survey the stability of the self: a testable hypothesis on the homeostatic role of TCR-MHC interactions.

@article{Bakacs2007TCS,
  title={T cells survey the stability of the self: a testable hypothesis on the homeostatic role of TCR-MHC interactions.},
  author={Tibor Bakacs and Jitendra N Mehrishi and Tam{\'a}s Szabados and L{\'a}szl{\'o} Varga and Mikl{\'o}s Szab{\'o} and G{\'a}bor E. Tusn{\'a}dy},
  journal={International archives of allergy and immunology},
  year={2007},
  volume={144 2},
  pages={171-82}
}
In the lifetime of an individual, every single gene will have undergone mutation on about 10(10) separate occasions. Nevertheless, cancer occurs mainly with advancing age. Here, we hypothesize that the evolutionary pressure driving the creation of the T cell receptor (TCR) repertoire was primarily the homeostatic surveillance of the genome. The subtly variable T cells may in fact constitute an evolutionary link between the invariable innate and hypervariable B cell systems. The new model is… CONTINUE READING