T cells potentiate PTH-induced cortical bone loss through CD40L signaling.

@article{Gao2008TCP,
  title={T cells potentiate PTH-induced cortical bone loss through CD40L signaling.},
  author={Yuhao Gao and Xiao-jun Wu and Masakazu Terauchi and J Li and Francesco Grassi and Sarah A Galley and Xiaoying Yang and Mervyn Neale Weitzmann and Roberto Pacifici},
  journal={Cell metabolism},
  year={2008},
  volume={8 2},
  pages={132-45}
}
Parathyroid hormone (PTH) promotes bone catabolism by targeting bone marrow (BM) stromal cells (SCs) and their osteoblastic progeny. Here we show that a continuous infusion of PTH that mimics hyperparathyroidism fails to induce osteoclast formation, bone resorption, and cortical bone loss in mice lacking T cells. T cells provide proliferative and survival cues to SCs and sensitize SCs to PTH through CD40 ligand (CD40L), a surface molecule of activated T cells that induces CD40 signaling in SCs… CONTINUE READING