T cells out of control—impaired immune regulation in the inflamed joint

  title={T cells out of control—impaired immune regulation in the inflamed joint},
  author={Ellen J M Wehrens and Berent Prakken and Femke van Wijk},
  journal={Nature Reviews Rheumatology},
Since the discovery of FOXP3+ regulatory T (TREG) cells over 15 years ago, intensive research has focused on their presence, phenotype and function in autoimmune disease. Whether deficiencies in TREG cells underlie autoimmune pathology and whether, or how, therapeutic approaches based on these cells might be successful is still the subject of debate. The potential role of TREG-cell extrinsic factors, such as proinflammatory cytokines and resistance of effector T cells to suppression, as the… CONTINUE READING
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