T cells lacking immunoproteasome subunits MECL-1 and LMP7 hyperproliferate in response to polyclonal mitogens.

@article{Caudill2006TCL,
  title={T cells lacking immunoproteasome subunits MECL-1 and LMP7 hyperproliferate in response to polyclonal mitogens.},
  author={Christy M Caudill and Krupakar Jayarapu and Laura A. Elenich and John J. Monaco and Robert A. Colbert and Thomas A. Griffin},
  journal={Journal of immunology},
  year={2006},
  volume={176 7},
  pages={4075-82}
}
Immunoproteasomes comprise a specialized subset of proteasomes that is defined by the presence of three catalytic immunosubunits: LMP2, MECL-1 (LMP10), and LMP7. Proteasomes in general serve many cellular functions through protein degradation, whereas the specific function of immunoproteasomes has been thought to be largely, if not exclusively, optimization of MHC class I Ag processing. In this report, we demonstrate that T cells from double knockout mice lacking two of the immunosubunits, MECL… CONTINUE READING

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