T cells isolated from patients with checkpoint inhibitor-resistant melanoma are functional and can mediate tumor regression.

@article{Andersen2018TCI,
  title={T cells isolated from patients with checkpoint inhibitor-resistant melanoma are functional and can mediate tumor regression.},
  author={Rikke S Andersen and Troels Holz Borch and Arianna Draghi and A Gokuldass and Mowadat Hussain Rana and Magnus Pedersen and Morten Agertoug Nielsen and Per Kongsted and Julie Westerlin Kjeldsen and Marie Christine Wulff Westergaard and H D Radic and Christine Chamberlain and Lisbet R H{\"o}lmich and Helle Westergren Hendel and Mathilde Skaarup Larsen and {\"O}zcan Met and Inge Marie Svane and Marco Donia},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2018},
  volume={29 7},
  pages={
          1575-1581
        }
}
Background Almost half of the patients with metastatic melanoma obtain only short-term or no benefit at all from checkpoint inhibitor (CPI) immunotherapy. In this study, we investigated whether the immune system of patients progressing following CPI treatment was able to generate functional tumor-specific immune responses. Materials and methods Tumor-infiltrating lymphocytes (TILs) were isolated and expanded from metastatic melanoma lesions which progressed during or after anti-programmed… CONTINUE READING