T cells in the human metastatic melanoma microenvironment express site-specific homing receptors and retention integrins.

@article{Salerno2014TCI,
  title={T cells in the human metastatic melanoma microenvironment express site-specific homing receptors and retention integrins.},
  author={Elise P. Salerno and Walter Olson and Chantel C. McSkimming and Sofia M. Shea and Craig L Slingluff},
  journal={International journal of cancer},
  year={2014},
  volume={134 3},
  pages={563-74}
}
T-cell infiltration into the metastatic melanoma microenvironment (MME) correlates with improved patient survival. However, diffuse infiltration into tumor occurs in only 8% of melanoma metastases. Little is known about mechanisms governing T-cell infiltration into human melanoma metastases or about how those mechanisms may be altered therapeutically. We hypothesized that T cells in the MME would be enriched for chemokine receptors CCR4, CCR5, CXCR3 and homing receptors relevant to the tissue… CONTINUE READING

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T u or Im m u ol og y Salerno et al. 573 Int. J. Cancer: 134, 563–574 • 2014

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