T-cells in alzheimer’s disease

  title={T-cells in alzheimer’s disease},
  author={Terrence C. Town and Jun Tan and Richard A Flavell and Mike Mullan},
  journal={NeuroMolecular Medicine},
Alzheimer’s disease (AD) is the most common dementing illness and is pathologically characterized by deposition of the 40–42 amino acid peptide, amyloid-β (Aβ), as senile plaques. It is well documented that brain inflammatory mechanisms mediated by reactive glia are activated in response to Aβ plaques. A number of reports further suggest that T-cells are activated in AD patients, and that these cells exist both in the periphery and as infiltrates in the brain. We explore the potential role of T… CONTINUE READING