T cells in ANCA-associated vasculitis: what can we learn from lesional versus circulating T cells?

@inproceedings{Wilde2010TCI,
  title={T cells in ANCA-associated vasculitis: what can we learn from lesional versus circulating T cells?},
  author={Benjamin Wilde and Marielle M Thewissen and Jan Damoiseaux and Pieter van Paassen and Oliver Witzke and Jan Willem Cohen Tervaert},
  booktitle={Arthritis research & therapy},
  year={2010}
}
Anti-neutrophil cytoplasmic antibody (ANCA) - associated vasculitis (AAV) is a life-threatening autoimmune disease characterized by an antibody-mediated glomerulonephritis and necrotizing vasculitis. Apart from antibodies, T cells are also involved in disease pathogenesis. This review stresses the hallmarks of T cell-mediated pathology in AAV and highlights the characteristics of lesional and circulating T cells in the immune response in AAV. Circulating effector T-cell populations are expanded… CONTINUE READING
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