T cells from patients with Hodgkin's disease have a defective T-cell receptor zeta chain expression that is reversible by T-cell stimulation with CD3 and CD28.

@article{Renner1996TCF,
  title={T cells from patients with Hodgkin's disease have a defective T-cell receptor zeta chain expression that is reversible by T-cell stimulation with CD3 and CD28.},
  author={Christoph Renner and Sascha Ohnesorge and Gerhard Held and Stefan Bauer and Wolfram Jung and J P Pfitzenmeier and Michael Pfreundschuh},
  journal={Blood},
  year={1996},
  volume={88 1},
  pages={236-41}
}
To investigate the mechanisms underlying the deficiency of T lymphocytes from patients with Hodgkin's disease, we investigated the expression of the T-cell receptor (TCR) zeta chain in patients with Hodgkin's disease. By flow cytometry using an anti-zeta chain monoclonal antibody, peripheral blood T lymphocytes from patients with untreated Hodgkin's disease were shown to express decreased levels of the TCR zeta chain. After stimulation by combined CD3 and CD28 cross-linking, T cells from… CONTINUE READING

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The role of lymphocyte subsets and adhesion molecules in T-cell dependent cytotoxicity mediated by CD3 and CD28 bispecific monoclonal antibodies

C Renner, W Jung, R van Lier, U Sahin, M Pfreundschuh
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