T cells from celiac disease lesions recognize gliadin epitopes deamidated in situ by endogenous tissue transglutaminase.

@article{Molberg2001TCF,
  title={T cells from celiac disease lesions recognize gliadin epitopes deamidated in situ by endogenous tissue transglutaminase.},
  author={Oyvind Molberg and Stephen McAdam and Knut E. A. Lundin and Christel Kristiansen and Helene Arentz-Hansen and Kjell Kett and Ludvig M. Sollid},
  journal={European journal of immunology},
  year={2001},
  volume={31 5},
  pages={1317-23}
}
Celiac disease is an HLA-DQ2-associated disorder characterized by intestinal T cell responses to ingested wheat gliadins. Initial studies used gliadin that had been subjected to non-enzymatic deamidation during pepsin/trypsin digestion to enrich for the gliadin-specific T cells in small intestinal celiac biopsies. These T cells recognized synthetic gliadin peptides only after their deamidation in vitro by purified tissue transglutaminase (tTG). However, as these studies used a deamidated… CONTINUE READING