T cells found in coronavirus patients 'bode well' for long-term immunity.

@article{Leslie2020TCF,
  title={T cells found in coronavirus patients 'bode well' for long-term immunity.},
  author={Mitch Leslie},
  journal={Science},
  year={2020},
  volume={368 6493},
  pages={
          809-810
        }
}
  • M. Leslie
  • Published 21 May 2020
  • Biology, Medicine
  • Science
Whether T cells join the immune system9s fight against SARS-CoV-2, the virus that causes COVID-19, has been unclear. Two new studies have identified T cells that react to the virus in patients who had COVID-19 or were recovering from it. Both studies detected helper T cells, which orchestrate antiviral responses of other immune cells, and one of the studies also found killer T cells that eliminate virally infected cells. Both studies also discovered helper T cells that target the virus in blood… 
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24 Citations
Background Citations
10
Results Citations
1

24 Citations

Alterations in Phenotypes and Responses of T Cells Within 6 Months of Recovery from COVID-19: A Cohort Study
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T cell responses experienced long-term alterations in phenotype and functional potential of LCR cohort, and remarkably, SARS-CoV-2 specific T cell responses in LCR were comparable to that of SCR.
Impairment of T cells' antiviral and anti-inflammation immunities may be critical to death from COVID-19
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It is proposed that T cells play a crucial role in the immunity against COVID-19, which provides a new direction–improvement of T cell number for advancing current prevention and treatment.
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This issue is looked at by screening studies that have experimentally addressed COVID-19 associated T cell specificities by presenting the identical T cell epitope VYIGDPAQL if presented by the MHC class I allele HLA-A*24:02.
Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges
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This study has provided the most updated evidence for the persistence of humoral and cellular immunity over a relatively longer period, and susceptibility to second infection for mutant coronavirus among convalescent patients.
Profiling of the immune repertoire in COVID-19 patients with mild, severe, convalescent, or retesting-positive status
Broad phenotypic alterations and potential dysfunction of lymphocytes in individuals clinically recovered from COVID-19
TLDR
The remarkable phenotypic alterations in lymphocytes in the CR cohort suggest that severe acute respiratory syndrome coronavirus 2 infection profoundly affects lymphocytes and potentially results in dysfunction even after clinical recovery.
The Frequency of SARS-CoV-2 Specific Memory B Cells in COVID-19 Recovered Patients Remain Stable While Antibodies Decay Over Time
TLDR
The data obtained in this study reveals a discordance between serological and cellular memory in COVID-19 recovered patients which has important implications on re-infection susceptibility and vaccine design.
Development of multi-epitope peptide-based vaccines against SARS-CoV-2
Immunogenicity Evaluating of the Multivalent COVID-19 Inactivated Vaccine against the SARS-CoV-2 Variants
TLDR
It is suggested that the multivalent CO VID-19 inactivated vaccine can provide broad spectrum protection against HB02 and other virus variants in humoral and cellular immunity, providing new ideas for the development of a broad-spectrum COVID-19 vaccine.
Continuous tracking of COVID-19 patients' immune status
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