T cells fail to develop in the human skin-cell explants system; an inconvenient truth

Abstract

Haplo-identical hematopoietic stem cell (HSC) transplantation is very successful in eradicating haematological tumours, but the long post-transplant T-lymphopenic phase is responsible for high morbidity and mortality rates. Clark et al. have described a skin-explant system capable of producing host-tolerant donor-HSC derived T-cells. Because this T-cell… (More)
DOI: 10.1186/1471-2172-12-17

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