T cells enhance gold nanoparticle delivery to tumors in vivo

  title={T cells enhance gold nanoparticle delivery to tumors in vivo},
  author={Laura C. Kennedy and Adham Sean Bear and Joseph Keith Young and Nastassja A Lewinski and J. P. Kim and Aaron Edward Foster and Rebekah A. Drezek},
  booktitle={Nanoscale research letters},
Gold nanoparticle-mediated photothermal therapy (PTT) has shown great potential for the treatment of cancer in mouse studies and is now being evaluated in clinical trials. For this therapy, gold nanoparticles (AuNPs) are injected intravenously and are allowed to accumulate within the tumor via the enhanced permeability and retention (EPR) effect. The tumor is then irradiated with a near infrared laser, whose energy is absorbed by the AuNPs and translated into heat. While reliance on the EPR… CONTINUE READING
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