T cells can be activated by peptides that are unrelated in sequence to their selecting peptide.

@article{Ignatowicz1997TCC,
  title={T cells can be activated by peptides that are unrelated in sequence to their selecting peptide.},
  author={Leszek Ignatowicz and W V Rees and Rafal Pacholczyk and Hanna Ignatowicz and E. Yu. Kushnir and John Kappler and Philippa Marrack},
  journal={Immunity},
  year={1997},
  volume={7 2},
  pages={179-86}
}
We tested the ability of CD4+ T cells, selected in the thymus by reaction with class II protein bound to a single peptide, to react with the same class II protein bound to other peptides. The T cells reacted with all peptides tested, including one that was quite unlike the selecting peptide in T cell receptor binding residues. The receptors on class II/peptide-reactive T cells from class II/single peptide mice were similar but not identical to some of those from normal animals. Thus, class II… CONTINUE READING

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