T cells and cytokines in intracellular bacterial infections: experiences with Mycobacterium bovis BCG.

@article{Kaufmann1995TCA,
  title={T cells and cytokines in intracellular bacterial infections: experiences with Mycobacterium bovis BCG.},
  author={Stefan H. E. Kaufmann and C. H. Ladel and Inge E. A. Flesch},
  journal={Ciba Foundation symposium},
  year={1995},
  volume={195},
  pages={123-32; discussion 132-6}
}
Intracellular bacteria reside in mononuclear phagocytes, and protective immunity is dominated by T lymphocytes. Mycobacterium bovis bacillus Calmette-Guéin (BCG) infection of mice represents an excellent model for studying immune mechanisms involved in defence against persistent intracellular bacteria that cause chronic disease. Gene disruption mutant mice include: A beta-/-, which lack conventional CD4+ T cell receptor alpha/beta (TCR alpha/beta) T lymphocytes; beta 2 microglobulin -/-, which… CONTINUE READING

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