T cells and B cells in chronic renal failure.

  title={T cells and B cells in chronic renal failure.},
  author={B{\'e}atrice Descamps-Latscha and Lucienne Chatenoud},
  journal={Seminars in nephrology},
  volume={16 3},
Recent knowledge into the pathophysiological mechanisms mediating the immune abnormalities characteristic of end-stage renal disease (ESRD) has focused on the dual activation versus deficiency state of immunocompetent cells. Despite major advances in renal replacement therapy, notably hemodialysis, no significant improvement in the immune status of uremic patients has been achieved. After a brief review of the role of T cells and B cells in the normal immune response, the functional and… CONTINUE READING


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