T cells, B cells, and polarized immune response in the pathogenesis of fibrosis and systemic sclerosis.

@article{Chizzolini2008TCB,
  title={T cells, B cells, and polarized immune response in the pathogenesis of fibrosis and systemic sclerosis.},
  author={Carlo Chizzolini},
  journal={Current opinion in rheumatology},
  year={2008},
  volume={20 6},
  pages={707-12}
}
PURPOSE OF REVIEW A better comprehension of the interactions between cells of the adaptive immune system with fibroblasts and endothelial cells is required to understand abnormal extracellular matrix deposition, development of pathologic fibrosis, and vasculopathy. RECENT FINDINGS Skin T cells with high IL-4 production potential and peripheral blood T cells preferentially expressing chemokine receptors associated with Th2 functions are found in individuals with active systemic sclerosis… CONTINUE READING
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