T cell zones of lymphoid organs constitutively express Th1 cytokine mRNA: specific changes during the early phase of an immune response.

@article{Kalies2006TCZ,
  title={T cell zones of lymphoid organs constitutively express Th1 cytokine mRNA: specific changes during the early phase of an immune response.},
  author={Kathrin Kalies and Maike Blessenohl and Julia Nietsch and J{\"u}rgen Westermann},
  journal={Journal of immunology},
  year={2006},
  volume={176 2},
  pages={
          741-9
        }
}
The cytokine milieu of the T cell zones in lymphoid organs is involved in the activation of naive T cells. Quantitative data regarding the local expression of cytokines are lacking. Therefore, the expression of Th1 (IL-2, IL-12p40, IFN-gamma), Th2 (IL-4, IL-10), as well as TGFbeta1 and IL-15 mRNA was studied after laser microdissection in the steady state and during an immune response in rats. Our results show that Th1 cytokines are preferentially found in lymphoid tissues and in the T cell… CONTINUE READING
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