T cell vaccination in multiple sclerosis: results of a preliminary study

@article{Zhang2002TCV,
  title={T cell vaccination in multiple sclerosis: results of a preliminary study},
  author={Jingwu Z. Zhang and Victor M. Rivera and Maria Victoria Tejada-Simon and Deye Yang and Jian Hong and Sufanfg Li and Hani Haykal and James K. Killian and Ying C. Q. Zang},
  journal={Journal of Neurology},
  year={2002},
  volume={249},
  pages={212-218}
}
Myelin basic protein (MBP)-reactive T cells are potentially involved in the pathogenesis of multiple sclerosis (MS), and can be depleted by subcutaneous inoculations with irradiated autologous MBP-reactive T cells (T cell vaccination). This preliminary open label study was undertaken to evaluate whether depletion of MBP-reactive T cells would be clinically beneficial to patients with MS. Fifty-four patients with relapsing-remitting (RR) MS (n=28) or secondary progressive (SP) MS (n=26) were… CONTINUE READING

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