T cell vaccination in experimental autoimmune encephalomyelitis: a mathematical model.

@article{Borghans1998TCV,
  title={T cell vaccination in experimental autoimmune encephalomyelitis: a mathematical model.},
  author={Jos{\'e} A. M. Borghans and Rob J de Boer and Eli E. Sercarz and V Kumar},
  journal={Journal of immunology},
  year={1998},
  volume={161 3},
  pages={1087-93}
}
T cell vaccination (TCV) is a method to induce resistance to autoimmune diseases by priming the immune system with autoreactive T cells. This priming evokes an anti-idiotypic regulatory T cell response to the receptors on the autoreactive T cells. Hence resistance is induced. To prevent the inoculated autoreactive cells from inducing autoimmunity, cells are given in a subpathogenic dose or in an attenuated form. We developed a mathematical model to study how the interactions between… CONTINUE READING