T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis.

@article{Allina2006TCT,
  title={T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis.},
  author={Jorge Allina and Bin Hu and Daniel Sullivan and Maria Isabel Fiel and Swan N. Thung and Steven F. Bronk and Robert Huebert and Judy Van de Water and Nicholas F. LaRusso and M Eric Gershwin and Gregory J. Gores and Joseph A. Odin},
  journal={Journal of autoimmunity},
  year={2006},
  volume={27 4},
  pages={232-41}
}
Primary biliary cirrhosis (PBC) is characterized by loss of tolerance against ubiquitously expressed mitochondrial autoantigens followed by biliary and salivary gland epithelial cell (BEC and SGEC) destruction by autoreactive T cells. It is unclear why BECs and SGECs are targeted. Previous work demonstrated that the reduced form of the major PBC autoantigen… CONTINUE READING