T cell survival and function requires the c-Abl tyrosine kinase.

@article{Silberman2008TCS,
  title={T cell survival and function requires the c-Abl tyrosine kinase.},
  author={Isabelle Silberman and Ronit Vogt Sionov and Valentina Zuckerman and Sue Haupt and Zehavit Goldberg and Andreas Strasser and Zami S Ben-Sasson and Michal Baniyash and Anthony J Koleske and Ygal Haupt},
  journal={Cell cycle},
  year={2008},
  volume={7 24},
  pages={
          3847-57
        }
}
C-Abl (Abl) regulates multiple cellular processes, including proliferation, survival, shape determination and motility, and participates in cellular responses to genotoxic and oxidative stress stimuli. Mice lacking Abl exhibit retarded growth, osteoporosis and defects in the immune system resulting in lymphopoenia and susceptibility to infections, leading to early death. To define the role of Abl in the regulation of adult T cells we ablated Abl exclusively in T cells by generating mice with… CONTINUE READING
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