T-cell suppression mediated by mesenchymal stem cells is deficient in patients with severe aplastic anemia.

Abstract

OBJECTIVE To compare the suppressive effect of mesenchymal stem cells (MSC), derived from normal individuals or severe aplastic anemia patients (SAA), on T-cell activation. PATIENTS AND METHODS We studied bone marrow MSC from 19 healthy donors and 23 SAA patients in different phases of the disease: at diagnosis (n = 3), following immunosuppressive therapy… (More)

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@article{Bacigalupo2005TcellSM, title={T-cell suppression mediated by mesenchymal stem cells is deficient in patients with severe aplastic anemia.}, author={Andrea Bacigalupo and Marisa Valle and Marina Podest{\`a} and Anna Pitto and Elena Zocchi and Antonio De Flora and S. Pozzi and Silvia Luchetti and Francesco Frassoni and Maria Teresa van Lint and Giovanna Piaggio}, journal={Experimental hematology}, year={2005}, volume={33 7}, pages={819-27} }