T-cell subset-specific expression of the IL-4 gene is regulated by a silencer element and STAT6.

@article{Kubo1997TcellSE,
  title={T-cell subset-specific expression of the IL-4 gene is regulated by a silencer element and STAT6.},
  author={Masato Kubo and John T. Ransom and Dennis Webb and Yasuhiro Hashimoto and Tomio Tada and Toshinori Nakayama},
  journal={The EMBO journal},
  year={1997},
  volume={16 13},
  pages={4007-20}
}
During development of CD4+ T lymphocytes in the periphery, differential expression of cytokine genes, such as those of interleukin (IL)-2 and IL-4, occurs in distinct T-cell subsets. IL-4 is a cytokine produced by T-helper 2 (Th2) cells, and the IL-4 receptor (IL-4R)-mediated signaling pathway is thought to be required for commitment to the Th2 phenotype. However, the molecular basis for development of the Th subset-specific production of IL-4 remains unclear. We demonstrate here that the IL-4… CONTINUE READING

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