T cell stimulating stratum corneum antigens: characterization by chromatography and electrophoresis indicates limited diversity.

As part of a search for T cell autoantigens in inflammatory skin diseases, we have demonstrated proteinase K sensitive, denaturation stable, T cell stimulatory material with antigenic properties in aqueous extracts of stratum corneum from normal human skin. Activity was also demonstrable in extracts of whole epidermis. A combination of preparative… CONTINUE READING