T-cell stimulating protein A (TspA) of Neisseria meningitidis is required for optimal adhesion to human cells.

@article{Oldfield2007TcellSP,
  title={T-cell stimulating protein A (TspA) of Neisseria meningitidis is required for optimal adhesion to human cells.},
  author={Neil J. Oldfield and Sarah Bland and Maria Taraktsoglou and Francisco J Dos Ramos and Karen Robinson and Karl G. Wooldridge and Dlawer A. A. Ala'Aldeen},
  journal={Cellular microbiology},
  year={2007},
  volume={9 2},
  pages={
          463-78
        }
}
T-cell stimulating protein A (TspA) is an immunogenic, T-cell and B-cell stimulating protein of Neisseria meningitidis. Sequence similarity between TspA and FimV, a Pseudomonas aeruginosa protein involved in twitching motility, suggested a link between TspA and type IV pili (Tfp). To determine the role of TspA an isogenic deletion mutant was created. Loss of TspA did not affect twitching motility or piliation indicating that there are functional differences between TspA and FimV. Mutation of… CONTINUE READING

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