T cell signaling abnormalities in systemic lupus erythematosus are associated with increased mutations/polymorphisms and splice variants of T cell receptor zeta chain messenger RNA.

@article{Nambiar2001TCS,
  title={T cell signaling abnormalities in systemic lupus erythematosus are associated with increased mutations/polymorphisms and splice variants of T cell receptor zeta chain messenger RNA.},
  author={Madhusoodana P. Nambiar and Edith J Enyedy and Vishal G. Warke and Sandeep H Krishnan and Glynn Dennis and Hon Kit Wong and Gary M. Kammer and George C Tsokos},
  journal={Arthritis and rheumatism},
  year={2001},
  volume={44 6},
  pages={1336-50}
}
OBJECTIVE T cells from patients with systemic lupus erythematosus (SLE) display antigen receptor-mediated signaling aberrations associated with defective T cell receptor (TCR) zeta chain protein and messenger RNA (mRNA) expression. This study was undertaken to explore the possibility that coding-region mutations/polymorphisms of the TCR zeta chain could account for its decreased expression and altered signaling in SLE T cells. METHODS TCR zeta chain mRNA from 48 SLE patients, 18 disease… CONTINUE READING

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