T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infection.

@article{Vallejo2004TcellSA,
  title={T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infection.},
  author={A N Vallejo and Cornelia M Weyand and J{\"o}rg J Goronzy},
  journal={Trends in molecular medicine},
  year={2004},
  volume={10 3},
  pages={119-24}
}
Long-lived clonal T cells deficient in CD28 expression are commonly found in patients with inflammatory syndromes and persistent infections. Considering that CD28 loss is the most consistent immunological marker of aging, we propose that, in pathological states, CD28(null) T cells represent prematurely senescent cells resulting from persistent immune activation. These unusual lymphocytes have aberrant functions that contribute to disease-related immune abnormalities, and the degree of… CONTINUE READING

From This Paper

Topics from this paper.
81 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 81 extracted citations

Similar Papers

Loading similar papers…