T cell responses in the central nervous system

@article{Korn2017TCR,
  title={T cell responses in the central nervous system},
  author={Thomas Korn and Axel Kallies},
  journal={Nature Reviews Immunology},
  year={2017},
  volume={17},
  pages={179-194}
}
T cells are required for immune surveillance of the central nervous system (CNS); however, they can also induce severe immunopathology in the context of both viral infections and autoimmunity. The mechanisms that are involved in the priming and recruitment of T cells to the CNS are only partially understood, but there has been renewed interest in this topic since the 'rediscovery' of lymphatic drainage from the CNS. Moreover, tissue-resident memory T cells have been detected in the CNS and are… CONTINUE READING
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