T cell responses are better correlates of vaccine protection in the elderly.

@article{McElhaney2006TCR,
  title={T cell responses are better correlates of vaccine protection in the elderly.},
  author={Janet E. McElhaney and Dongxu Xie and William D. Hager and Mary Beth Barry and Yazhen Wang and Alison Kleppinger and Catherine Ewen and Kevin P. Kane and Robert Chris Bleackley},
  journal={Journal of immunology},
  year={2006},
  volume={176 10},
  pages={6333-9}
}
It is commonly held that increased risk of influenza in the elderly is due to a decline in the Ab response to influenza vaccination. This study prospectively evaluated the relationship between the development of influenza illness, and serum Ab titers and ex vivo cellular immune responses to influenza vaccination in community dwelling older adults including those with congestive heart failure (CHF). Adults age 60 years and older (90 subjects), and 10 healthy young adult controls received the… CONTINUE READING

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