T cell response to myelin basic protein epitopes in multiple sclerosis patients and healthy subjects.

@article{Liblau1991TCR,
  title={T cell response to myelin basic protein epitopes in multiple sclerosis patients and healthy subjects.},
  author={Roland S Liblau and Elisabeth Tournier-Lasserve and Jacqueline Maciazek and G{\'e}rard Dumas and Odile Siffert and George Hashim and Marc A. Bach},
  journal={European journal of immunology},
  year={1991},
  volume={21 6},
  pages={1391-5}
}
T cell lines and clones specific for human myelin basic protein (BP) were selected from three multiple sclerosis (MS) patients and two healthy subjects and tested for their proliferative responses to a battery of synthetic peptides, 9 to 21 amino acid residues long. The combined amino acid sequence of the peptides spanned the complete sequence of the human BP. The results suggest the development of T cells sensitized to at least four independent regions of the human BP, indicating some… CONTINUE READING

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