T-cell response to gluten in patients with HLA-DQ2.2 reveals requirement of peptide-MHC stability in celiac disease.

@article{Bodd2012TcellRT,
  title={T-cell response to gluten in patients with HLA-DQ2.2 reveals requirement of peptide-MHC stability in celiac disease.},
  author={Michael Bodd and C Kim and Knut E. A. Lundin and Ludvig M. Sollid},
  journal={Gastroenterology},
  year={2012},
  volume={142 3},
  pages={552-61}
}
BACKGROUND & AIMS Celiac disease is a diet-induced, T cell-mediated enteropathy. The HLA variant DQ2.5 increases risk of the disease, and the homologous DQ2.2 confers a lower level of risk. As many as 5% of patients with celiac disease carry DQ2.2 without any other risk alleles. Epitopes commonly recognized by T cells of patients with HLA-DQ2.5 bind stably to DQ2.5 but unstably to DQ2.2. We investigated the response to gluten in patients with HLA-DQ2.2. METHODS We generated intestinal T-cell… CONTINUE READING
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